Análisis Evolutivo de Las Redes de Regulación Génica Dependientes de IYO/RIMA que dirigen la Diferenciación Celular (PGC2018-094257-B-C22)
Cell differentiation is an essential, necessary step for the proper development of structures and organs of multicellular organisms. However, very little is known about the molecular mechanisms driving the activation of cell differentiation. Recently, the characterization of the binary switcher MINIYO/RIMA in Arabidopsis, and its orthologue in animals, has started to unmask how this fundamental process for the development is activated, also openning the possibility to investigate if the mechanisms of cell differentiation are evolutionary conserved in plants. Research in our group is focused on understanding how these mechanisms have evolved, using Marchantia polymorpha as a model system, due to its low genetic redundancy, its possition in the evolutionary tree, and the availability of molecular tools.
The final goal of these comparative studies is to identify the common, key factors triggering the cell differentiation in different organisms, so that they can be used in future biotechnological applications. In order to be able to find how and when stem cells go to differentiation, losing their pluripotency, is crucial to understand the development of the organisms, as well as other processes such as tissue regeneration and cell reprogramming. That's why the comparison of the function of the IYO/RIMA switcher in evolutionary distant plants as Arabidopsis and Marchantia, will help to discover the conserved mechanisms involved in the start of cell differentiation in any plant, as well as novel factors and processes evolving separately in different lineages.
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