Research groups

Grupo: Regulation of Cell Differentiation in Plants

Cell differentiation is an essential, necessary step for the proper development of structures and organs of multicellular organisms. However, very little is known about the molecular mechanisms driving the activation of cell differentiation. Recently, the characterization of the binary switcher MINIYO/RIMA in Arabidopsis, and its orthologue in animals, has started to unmask how this fundamental process for the development is activated, also openning the possibility to investigate if the mechanisms of cell differentiation are evolutionary conserved in plants. Research in our group is focused on understanding how these mechanisms have evolved, using Marchantia polymorpha as a model system, due to its low genetic redundancy, its possition in the evolutionary tree, and the availability of molecular tools.

The final goal of these comparative studies is to identify the common, key factors triggering the cell differentiation in different organisms, so that they can be used in future biotechnological applications. In order to be able to find how and when stem cells go to differentiation, losing their pluripotency, is crucial to understand the development of the organisms, as well as other processes such as tissue regeneration and cell reprogramming. That's why the comparison of the function of the IYO/RIMA switcher in evolutionary distant plants as Arabidopsis and Marchantia, will help to discover the conserved mechanisms involved in the start of cell differentiation in any plant, as well as novel factors and processes evolving separately in different lineages.

Lab Staff

Staff Researchers

Other Group Members

  • Sanmartín M, Sauer M, Muñoz A, Rojo E (2012)
    MINIYO and transcriptional elongation: lifting the roadblock to differentiation
    Transcription 3(1): 25-28
  • Sanmartín M, Sauer M, Muñoz A, Zouhar J, Ordóñez A, van de Ven W, Caro E, Sánchez MP, Raikhel NV, Gutiérrez C, Sánchez-Serrano JJ, Rojo E (2011)
    A molecular switch for initiating cell differentiation in Arabidopsis
    Current Biology 21(12): 999-1008
  • Domínguez T, Hernández ML, Pennycooke JC, Jiménez P, Martínez-Rivas JM, Sanz C, Stockinger EJ, Sánchez-Serrano JJ, Sanmartín M (2010)
    Modification of omega-3 desaturase expression in tomato results in altered aroma profile and increased resistance to cold stress.
    Plant Physiology 53(2): 655-665
  • Moschou P, Sanmartin M, Andriopoulou A, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis K (2008)
    Bridging the gap between plant and mammalian polyamine metabolism: A novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis thaliana
    Plant Physiology 147 (4): 1845-1857

Análisis Evolutivo de Las Redes de Regulación Génica Dependientes de IYO/RIMA que dirigen la Diferenciación Celular (PGC2018-094257-B-C22)

Entidad financiadora: 
Proyecto I+D - Subprograma Estatal de Generación de Conocimiento
IP: 
Maite Sanmartín Artiñano
Regulación De La Diferenciación Celular En Plantas (201840i083)
Entidad financiadora: 
Programa de Incentivación, de Incorporación e Intensificación de la Actividad Investigadora
IP: 
Maite Sanmartín Artiñano
Modulación de la Actividad de IYO Y ART para Entender la Renovación Y Diferenciación de Células Madre en Plantas (CoIP; BIO2015-69582-P PN2015)
Entidad financiadora: 
Proyecto I+D - Subprograma Estatal de Generación de Conocimiento
IP: 
Maite Sanmartín Artiñano