Biografía
Current Postions:
Full Professor (Department of Biotechnology, Polytechnic University of Valencia, Spain)
Group Leader (AbiotiK+ stress-Potassium transport in Abiotic Stress in plants and yeast, IBMCP)
Vicedirector IBMCP 2009-present
Director of the Doctoral School of the UPV 2021-present
Previous posts:
Post-doctoral fellowships in Prof. Ramón Serrano's laboratory 1998-2006 (National Science Foundation, European Molecular Biology Organization, Ramón y Cajal, IBMCP, Valencia, Spain)
Education:
PhD Harvard Medical School 1997 (Essential Elements of Insulin-Stimulated Growth and Survival, Director Morris F. White Joslin Diabetes Center, Boston, MA, USA)
Bachelor of Science 1992 (Wheaton College, Norton, MA, USA)
Publicaciones destacadas
Multigene Engineering by GoldenBraid Cloning: From Plants to Filamentous Fungi and Beyond. Vazquez-Vilar M, Gandía M, García-Carpintero V, Marqués E, Sarrion-Perdigones A, Yenush L, Polaina J, Manzanares P, Marcos JF, Orzaez D. Curr Protoc Mol Biol. 2020 Mar;130(1):e116.
BCL2-ASSOCIATED ATHANOGENE4 Regulates the KAT1 Potassium Channel and Controls Stomatal Movement. Locascio A, Marqués MC, García-Martínez G, Corratgé-Faillie C, Andrés-Colás N, Rubio L, Fernández JA, Véry AA, Mulet JM, Yenush L.
Plant Physiol. 2019 Nov;181(3):1277-1294.
Saccharomyces cerevisiae as a Tool to Investigate Plant Potassium and Sodium Transporters. Locascio A, Andrés-Colás N, Mulet JM, Yenush L. Int J Mol Sci. 2019 Apr 30;20(9):2133.
FungalBraid: A GoldenBraid-based modular cloning platform for the assembly and exchange of DNA elements tailored to fungal synthetic biology. Hernanz-Koers M, Gandía M, Garrigues S, Manzanares P, Yenush L, Orzaez D, Marcos JF. Fungal Genet Biol. 2018 Jul;116:51-61.
Reciprocal Regulation of Target of Rapamycin Complex 1 and Potassium Accumulation.
Primo C, Ferri-Blázquez A, Loewith R, Yenush L. J Biol Chem. 2017 Jan 13;292(2):563-574
Regulation of the Yeast Hxt6 Hexose Transporter by the Rod1 α-Arrestin, the Snf1 Protein Kinase and the Bmh2 14-3-3 Protein. Llopis-Torregrosa V, Ferri-Blázquez A, Adam-Artigues A, Deffontaines E, van Heusden GP, Yenush L. J Biol Chem. 2016 Jul 15;291(29):14973-85.
Arabidopsis COGWHEEL1 links light perception and gibberellins with seed tolerance to deterioration. Bueso E, Muñoz-Bertomeu J, Campos F, Martínez C, Tello C, Martínez-Almonacid I, Ballester P, Simón-Moya M, Brunaud V, Yenush L, Ferrándiz C, Serrano R. Plant J. 2016 May 26. doi: 10.1111/tpj.13220. [Epub ahead of print]
Potassium and Sodium Transport in Yeast. Yenush L. Adv Exp Med Biol. 2016;892:187-228. doi: 10.1007/978-3-319-25304-6_8.
A functional Rim101 complex is required for proper accumulation of the Ena1 Na+-ATPase protein in response to salt stress in Saccharomyces cerevisiae. Marqués MC, Zamarbide-Forés S, Pedelini L, Llopis-Torregrosa V, Yenush L. FEMS Yeast Res. 2015 Jun;15(4). pii: fov017. doi: 10.1093/femsyr/fov017.
Potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling. Kahm M, Navarrete C, Llopis-Torregrosa V, Herrera R, Barreto L, Yenush L, Ariño J, Ramos J, Kschischo M. PLoS Comput Biol. 2012;8(6):e1002548. doi: 10.1371/journal.pcbi.1002548. Epub 2012 Jun 21.
Key role for intracellular K+ and protein kinases Sat4/Hal4 and Hal5 in the plasma membrane stabilization of yeast nutrient transporters. Pérez-Valle J, Jenkins H, Merchan S, Montiel V, Ramos J, Sharma S, Serrano R, Yenush L. Mol Cell Biol. 2007 Aug;27(16):5725-36. Epub 2007 Jun 4.
pH-Responsive, posttranslational regulation of the Trk1 potassium transporter by the type 1-related Ppz1 phosphatase. Yenush L, Merchan S, Holmes J, Serrano R. Mol Cell Biol. 2005 Oct;25(19):8683-92.
The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. Yenush L, Mulet JM, Ariño J, Serrano R. EMBO J. 2002 Mar 1;21(5):920-9.
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). Aguirre V, Uchida T, Yenush L, Davis R, White MF. J Biol Chem. 2000 Mar 24;275(12):9047-54.
The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin. Yenush L, Zanella C, Uchida T, Bernal D, White MF. Mol Cell Biol. 1998 Nov;18(11):6784-94.
The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis. Yenush L, Fernandez R, Myers MG Jr, Grammer TC, Sun XJ, Blenis J, Pierce JH, Schlessinger J, White MF. Mol Cell Biol. 1996 May;16(5):2509-17.
Role of IRS-2 in insulin and cytokine signalling. Sun XJ, Wang LM, Zhang Y, Yenush L, Myers MG Jr, Glasheen E, Lane WS, Pierce JH, White MF. Nature. 1995 Sep 14;377(6545):173-7.