Alejandro Ferrando holds a degree in Biology from the University of Valencia, Spain. In 1995 he received his Ph.D. from the Polytechnic University of Valencia after his work, supervised by Professor Ramón Serrano, on the isolation by overexpression of halotolerant genes and their characterization in the model organism S.cerevisiae. From 1995 to 2001 he moved, as a postdoc, to the Max Planck Institute for Plant Breeding Research in Cologne, Germany, to learn the equivalent genetic approach for plant cells ‘Activation Tagging’ at the department led by Jeff Schell. In the same department he collaborated to elucidate protein complexes involved in glucose signalling at the Csaba Koncz’s lab where he designed and implemented the ‘Intron-tagged epitope’ technique. He then moved back to Spain as a postdoc, first from 2001 to 2003 in the lab of Pere Puigdomènech at the Institute of Molecular Biology of Barcelona. Later, from 2003 to 2004, he joined the Antonio F. Tiburcio’s lab at the Plant Physiology Department of the University of Barcelona to initiate his studies on polyamine metabolism and abiotic stress in plants including the pioneer design and use of the Bi-molecular Fluorescence Complementation technology (BiFC) for protein interaction studies in plant cells. In 2004 he obtained a Ramón y Cajal contract at the Biochemistry Department of the University of Valencia where he combined teaching Biochemistry and Molecular Biology with research on plant polyamine metabolism.
In 2009 he initiated his work as Staff Scientist of the Spanish Research Council at the Institute of Plant Molecular and Cellular Biology (IBMCP) with the aim, as a Group Leader, to elucidate the molecular mechanisms of polyamine action. More specifically, current interests of the Ferrando’s lab at the IBMCP include deciphering the functions of spermidine and thermospermine as metabolites involved in mRNA surveillance and translation control mechanisms required for plant growth, development and adaptation to environmental challenges.
- Ferrando A, Farràs R, Jásik J, Schell J, and Koncz C. Intron-tagged epitope: a tool for facile detection and purification of proteins expressed in Agrobacterium-transformed plant cells. The Plant Journal 22 (6), 553-560 (2000)
- Farràs R, Ferrando A, Jásik J, Kleinow T, Ökréz L, Tiburcio A, Salchert K, del Pozo C, Schell J, and Koncz C. SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase. The EMBO Journal 20 (11), 2742-2756 (2001)
- Panicot M, Minguet E, Ferrando A, Alcázar R, Blázquez MA, Carbonell J, Altabella T, Koncz C and Tiburcio AF. A polyamine metabolon involving aminopropyl transferase complexes in Arabidopsis. The Plant Cell 14 (10), 2539-2551 (2002)
- Cuevas JC, López-Cobollo R, Alcázar R, Zarza R, Koncz C, Altabella T, Salinas J, Tiburcio AF, Ferrando A. Putrescine is involved in Arabidopsis freezing tolerance and cold acclimation by regulating ABA levels in response to low temperature. Plant Physiology 148, 1094-1105 (2008)
- Belda-Palazón B, Ruiz L, Martí E, Culiañez F, Tárraga S, Farràs R, Carrasco P, Tiburcio AF, Ferrando A. Aminopropyltransferases Involved in Polyamine Biosynthesis Localize Preferentially in the Nucleus of Plant Cells. PLoS ONE 7(10): e46907 (2012). Doi:10.1371/journal.pone.0046907
- Belda-Palazón B., Nohales M.A., Rambla J.L., Aceña J.L., Delgado O., Fustero S., Martínez M.C., Granell A., Carbonell J., and Ferrando A. Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulation. Frontiers in Plant Science 5: (2014). Doi: 10.3389/fpls.2014.00202
- Li T., Belda-Palazón B., Ferrando A, and Alepuz P. Fertility and polarized cell growth depends on eIF5A for translation of polyproline-rich formins in S.cerevisiae. Genetics 197 (4): 1191-1200 (2014). Doi: 10.1534/genetics.114.166926
- Belda-Palazon, B., Almendáriz C., Martí E., Carbonell J, and Ferrando A. Relevance of the axis Spermidine/eIF5A for plant growth and development. Frontiers in Plant Science (2016). Doi: 10.3389/fpls.2016.00245