Our laboratory is focused in the mechanism that underlies the high degree of plasticity of plant development. The kind of questions that drive our research are:
- How does the plant integrate all the environmental cues (light, temperature, etc) and endogenous signals (age, nutritional state, etc) to trigger the most appropriate developmental program in a given stage?
- How do plants distinguish between signals and noise?
- What is the adaptive value of the hormone signaling pathways that we know?
- These regulatory circuits that direct growth, how have they evolved?
Our hypothesis is that plasticity is inherent to the very architecture of the signaling networks: the extended connectivity between hormone and environmental signaling pathways provides robustness and flexibility to plant development. Almost all our current work is devoted to the study of gibberellins, auxins and brassinosteroids in Arabidopsis, tomato, rice and Marchantia polymorpha, and we use a combination of molecular genetic, biochemical, and genomic approaches.
A recent milestone in our research line has been the elucidation of the mechanism by which DELLA proteins act as molecular 'hubs' in the signaling networks that control plant responses to the environment. We have found that DELLA levels are the result of environmental conditions (light, temperature) in addition to the daily oscilation imposed by the circadian clock. And DELLAs, in turn, relay environmental information to the cell by interacting physically with a large number of transcription factors, thereby coordinating multiple cell responses.
From the perspective of developmental processes that we focus on, two are particularly exciting for us : photomorphogenesis and secondary growth. Photomorphogenesis is the developmental program that plants follow in the presence of light, as opposed to darkness, and it is also influenced by other signals like temperature and oxygen levels. Secondary growth is the growth in girth of certain organs, which is caused by radial expansion of the vasculature and is the basis for wood formation in many plant species. It largely depends on environmental conditions, such as temperature, and also on the age of the plant.
Please contact us for more details on current projects
Other Group Members
Serrano-Mislata, A., Goslin, K., Zheng, B., Rae. L., Wellmer, F., Graciet E. and Madueño F (2018)Regulatory interplay between LEAFY, APETALA1/CAULIFLOWER and TERMINAL FLOWER1: New insights into an old relationshipPlant Signalling and Behavior 12, 10, e1370164
Gras DE, Vidal EA, Undurraga SF, Riveras E, Alabadí D, Blázquez MA, Medina J, Gutiérrez RA (2018)SMZ/SNZ and gibberellin signaling are required for nitrate-elicited delay of flowering time in Arabidopsis thalianaJournal of Experimental Botany. 69: 619-631.
Serrano-Mislata, A. and Sablowski, R (2018)The pillars of land plants: new insights into stem developmentCurrent Opinion in Plant Biology 45(A), 11-17
Briones-Moreno A, Hernández-García J, Vargas-Chávez C, Romero-Campero FJ, Romero JM, Valverde F, Blázquez MA (2017)Evolutionary analysis of DELLA-associated transcriptional networksFrontiers in Plant Science. 8: 626
López-Moya F, Escudero N, Zavala-González EA, Esteve-Bruna D, Blázquez MA, Alabadí D, López-Llorca LV (2017)Induction of auxin biosynthesis and WOX5 repression mediate changes in root development in Arabidopsis exposed to chitosanScientific Reports. 7: 16813.
Abbas M, Hernández-García J, Blanco-Touriñán N, Aliaga N, Minguet EG, Alabadí D, Blázquez MA (2017)Reduction of IAA Methyltransferase activity compensates for high-temperature male sterility in ArabidopsisPlant Biotechnology Journal 16: 272-279.
Blanco-Tourinan N, Lechon T, Palomares V, Sanz L, Blazquez MA, Lorenzo O (2016)Involvement of prohibitin in nitric oxide (NO) homeostasis during developmental processes and salt stress in arabidopsis
New Biotechnology 33: 412-412
Felipo-Benavent A, Blanco-Tourinan N, Martinelli F, Blazquez MA, Alabadi D (2016)New role of sawtooth transcription factors in the shift to photoautotrophic growth in plants
New Biotechnology 33: 425-425
Abbas M, Hernandez-Garcia J, Blazquez MA, Alabadi D (2016)Reduction of IAA methyltransferase activity compensates for high-temperature male sterility in Arabidopsis
New Biotechnology 33: 435-435
Vera-Sirera F,De Rybel B,Urbez C, Kouklas E, Pesquera M, Álvarez-Mahecha JC, Minguet Eg, Tuominen H, Carbonell J, Borst JW, Weijers D, Blázquez MA (2015)A bHLH-Based Feedback Loop Restricts Vascular Cell Proliferation in Plants
Developmental Cell 35: 432-443
Papel de la prefoldina en el núcleo dependiente de DELLAs en Arabidopsis [PRENUC] (BIO2013-43184-P), 01-01-2014/30-06-2017.
Señalización por giberelinas dependiente del contexto en Arabidopsis [ANACONGA] (BIO2010-15071), 28-12-2010/30-06-2014.
Function and biotechnological potential of transcription factors in plants. TRANSPLANTA (CONSOLIDER 2007), 01-02-2008/02-02-2013
Interacciones moleculares implicadas en la señalización por giberelinas en Arabidopsis (BIO2004-02355), 01-01-2005/31-12-2007
Ramificaciones de la vía de señalización por giberelinas en Arabidopsis (BIO2001-1558), 01-01-2002/31-12-2004
Análisis funcional de la interacción entre hormonas y luz mediante Genómica Química (PIB2010AR-00468), 08-12-2010/07-12-2013.
Obtención y caracterización de mutantes de inserción (T-DNA) de Arabidopsis (GEN2001-4890-CO7-05), 01-07-2002/30-06-2005
Identificación de nuevos fármacos con aplicaciones biotecnológicos en cultivos mediante un abordaje ge Genética Química (PROMETEO 2010/020), 01-06-2010/31-12-2010